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Objective
High‐fat diet (HFD) is known to induce low‐grade hypothalamic inflammation. Whether inflammation occurs in other brain areas remains unknown. This study tested the effect of short‐term HFD on cytokine gene expression and identified leukemia inhibitory factor (LIF) as a responsive cytokine in the brain stem. Thus, functional and cellular effects of LIF in the brain stem were investigated...
Glutamate plays a predominant role in regulating the activity of orexin neurons that coordinate motivated behaviors, sleep-wake cycle and autonomic functions. To gain more insight into the properties of excitatory transmission to orexin neurons, whole cell patch clamp recordings were made in rat brain slices and quantal analysis of pharmacologically isolated miniature excitatory postsynaptic currents...
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