Chiara Traini

article

Muscularis macrophages establish cell‐to‐cell contacts with telocytes/PDGFRα‐positive cells and smooth muscle cells in the human and mouse gastrointestinal tract

Sihan Ji, Chiara Traini, Magdalini Mischopoulou, Simon J. Gibbons, more

Neurogastroenterology & Motility > 33 > 3 > n/a - n/a

Background and Aim Muscularis macrophages (MMs) not only mediate the innate immunity, but also functionally interact with cells important for gastrointestinal motility. The aim of this study was to determine the spatial relationship and types of contacts between the MMs and neighboring cells in the muscularis propria of human and mouse stomach, small intestine, and large intestine. Methods The...

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The asymmetric innervation of the circular and longitudinal muscle of the mouse colon differently modulates myogenic slow phasic contractions

Sara Traserra, Sonia Villarte, Chiara Traini, Sara Palacin, more

Neurogastroenterology & Motility > 32 > 4 > n/a - n/a

Background Neuromuscular transmission has been extensively studied in the circular layer of the mouse colon where a co‐transmission of purines acting on P2Y₁ receptors and NO has been previously described. However, the corresponding mechanisms in the longitudinal layer are less known. Methods Electrophysiological and myography techniques were used to evaluate spontaneous phasic contractions (SPC)...

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γEpithelial Na⁺ Channel (γENaC) and the Acid‐Sensing Ion Channel 1 (ASIC1) expression in the urothelium of patients with neurogenic detrusor overactivity

Chiara Traini, Giulio Del Popolo, Massimo Lazzeri, Katia Mazzaferro, more

BJU International > 116 > 5 > 797 - 804

ObjectiveTo investigate the expression of two types of cation channels, γEpithelial Na⁺Channel (γENaC) and the Acid‐Sensing Ion Channel 1 (ASIC1), in the urothelium of controls and in patients affected by neurogenic detrusor overactivity (NDO). In parallel, urodynamic parameters were collected and correlated to the immunohistochemical results. Patients Subjects and MethodsFour controls and 12 patients...

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Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N

Francesca Tatini, Anna Maria Pugliese, Chiara Traini, Sandra Niccoli, more

Neurobiology of Aging > 2013 > 34 > 9 > 2100-2109

Protein misfolded oligomers are thought to be the primary pathogenic species in many protein deposition diseases. Oligomers by the amyloid-β peptide play a central role in Alzheimer's disease pathogenesis, being implicated in synaptic dysfunction. Here we show that the oligomers formed by a protein that has no link with human disease, namely the N-terminal domain of HypF from Escherichia coli (HypF-N),...

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Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A2A adenosine receptors

Giovanna Maraula, Chiara Traini, Tommaso Mello, Elisabetta Coppi, more

Neuropharmacology > 2013 > 67 > Complete > 511-520

The hippocampus is comprised of two distinct subfields that show different responses to hypoxic-ischemic brain injury: the CA1 region is particularly susceptible whereas the dentate gyrus (DG) is quite resistant. Our aim was to determine the synaptic and proliferative response of the DG to severe oxygen and glucose deprivation (OGD) in acute rat hippocampal slices and to investigate the contribution...

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Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: A study in APP mutant mice

Ilaria Luccarini, Cristina Grossi, Chiara Traini, Anna Fiorentini, more

Neuroscience Letters > 2012 > 506 > 1 > 94-99

The purpose of this study was to investigate the microglia-driven apoptosis and the Aβ deposits triggered generation of new microglial cells in the neocortex of TgCRND8 mice. Three- and seven-month-old TgCRND8 mice, displaying an early and widespread amyloid deposition, respectively, were used. In 7-month-old TgCRND8 mice the Aβ-associated glial reaction was accompanied by an intense immunoreactivity...

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P2 receptor antagonists prevent synaptic failure and extracellular signal‐regulated kinase1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro

Chiara Traini, Felicita Pedata, Sara Cipriani, Tommaso Mello, more

European Journal of Neuroscience > 33 > 12 > 2203 - 2215

To investigate the role of purinergic P2 receptors under ischemia, we studied the effect of P2 receptor antagonists on synaptic transmission and mitogen‐activated protein kinase (MAPK) activation under oxygen and glucose deprivation (OGD) in rat hippocampal slices. The effect of the P2 antagonists pyridoxalphosphate‐6‐azophenyl‐2′,4′‐disulfonate (PPADS, unselective, 30 μm), N⁶‐methyl‐2′‐deoxyadenosine‐3′,5′‐bisphosphate...

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Pyrido[2,3- e ]-1,2,4-triazolo[4,3- a ]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A ₃ Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies

Vittoria Colotta, Ombretta Lenzi, Daniela Catarzi, Flavia Varano, more

Journal of Medicinal Chemistry > 2009 > 52 > 8 > 2407 - 2419

article

Synthesis, ligand–receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists

Vittoria Colotta, Daniela Catarzi, Flavia Varano, Ombretta Lenzi, more

Bioorganic & Medicinal Chemistry > 2008 > 16 > 11 > 6086-6102

The study of some 4-substituted-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives, designed as hA ₃ adenosine receptor antagonists, is reported. The new compounds bear on the four-position different acylamino, sulfonylamino, benzylureido and benzyloxy moieties, which have also been combined with a para-methoxy group on the 2-phenyl ring or with a nitro residue at the six-position. Many...

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Search results for: Chiara Traini

Muscularis macrophages establish cell‐to‐cell contacts with telocytes/PDGFRα‐positive cells and smooth muscle cells in the human and mouse gastrointestinal tract

The asymmetric innervation of the circular and longitudinal muscle of the mouse colon differently modulates myogenic slow phasic contractions

γEpithelial Na⁺ Channel (γENaC) and the Acid‐Sensing Ion Channel 1 (ASIC1) expression in the urothelium of patients with neurogenic detrusor overactivity

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N

Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A2A adenosine receptors

Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: A study in APP mutant mice

P2 receptor antagonists prevent synaptic failure and extracellular signal‐regulated kinase1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro

Pyrido[2,3- e ]-1,2,4-triazolo[4,3- a ]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A ₃ Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies

Synthesis, ligand–receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists

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