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Adrenocorticotropin (ACTH)-producing pituitary adenomas are derived from corticotroph cells in the anterior pituitary gland. Most of them secrete excess ACTH leading to cortisol overproduction or Cushing’s disease. However, ACTH-producing pituitary tumors are heterogeneous and differ in histologic, immunohistochemical, and ultrastructural findings as well as in clinical presentations and prognosis...
α-Synuclein is a major constituent of Lewy bodies, the fibrillar aggregates that form within neurons in Parkinson’s disease and dementia with Lewy bodies (DLB). Recent biochemical data show that α-synuclein accumulates in Parkinson’s disease in a detergent insoluble form. We now examine the relationship between detergent insoluble α-synuclein and the presence of Lewy bodies, clinical measures of dementia...
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