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Background
Tinea pedis is often chronic or recurrent, but not all individuals are equally susceptible to this infection. Dermatophytes are able to induce the expression of antimicrobial peptides and proteins (AMPs) in human keratinocytes and certain AMPs can inhibit the growth of dermatophytes.
Objective
The focus of this study was to analyse the secretion of relevant AMPs, especially RNase 7,...
Introduction
It was shown previously that dermatophytes can markedly be inhibited by a photochemical treatment with curcumin. This kind of photo‐inactivation needs to be improved, however, because curcumin is poorly water‐soluble. Therefore, a new water‐soluble γ‐cyclodextrin formulation of curcuminoids was tested for its photochemical inactivation of Trichophyton (T.) rubrum.
Materials and methods...
A 60‐year‐old woman presented with a nodular granulomatous skin lesion on her right thumb. It had developed after inoculation of a splinter of wood. Because it was resistant to various therapies, the nodule was finally excised. Complete healing followed this surgery and a melanised filamentous fungus with scopulariopsis‐like morphology was recovered from the dermal tissue. Fitting with no known species,...
A 68‐year‐old woman was submitted to our hospital because of erythematous and scaly skin lesions. To exclude tinea samples of stratum corneum were collected and used for mycological investigations. In this material, no fungal elements were detected microscopically, but inoculation on Sabouraud agar with cycloheximide yielded a presumptive dermatophyte fungus. Subsequent detailed investigations with...
Recently, we had shown that conidia‐derived growth of many dermatophytes can be inhibited by curcumin plus exposure to visible light. This method of photo inactivation should be developed further aiming for an option to stop mycelial growth in superficial tinea. Wells of microtitre plates were inoculated with either mycelial or conidial elements collected from 5 strains of Trichophyton rubrum. Then...
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