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Background
Rescue of mitochondrial function is a promising neuroprotective strategy for Parkinson's disease (PD). Ursodeoxycholic acid (UDCA) has shown considerable promise as a mitochondrial rescue agent across a range of preclinical in vitro and in vivo models of PD.
Objectives
To investigate the safety and tolerability of high‐dose UDCA in PD and determine midbrain target engagement.
Methods...
This paper aims at the development of a comprehensive procedure for detecting oil debris contents, as well as analysing other physical parameters associated with lubricating oil degradation, using a combination of ultrasonic, capacitance and inductance‐based measurements. Brief explanations, accompanied by the derivation of closed‐form expressions that demonstrate the physical sensing mechanisms utilised...
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