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BackgroundA subclinical, hepatic involvement in manifest and premanifest Huntington's disease (HD) was recently demonstrated by using the 13C‐methionine breath test (MeBT). In this longitudinal pilot study, we investigated whether there is evidence for progressive hepatic mitochondrial dysfunction in premanifest HD.
MethodsThe MeBT was performed within a group of 25 well‐characterized premanifest...