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Loss of circadian rhythmicity fundamentally affects the neuroendocrine, immune, and autonomic system, similar to chronic stress and may play a central role in the development of stress‐related disorders. Recent articles have focused on the role of sleep and circadian disruption in the pathophysiology of posttraumatic stress disorder (PTSD), suggesting that chronodisruption plays a causal role in PTSD...
• The extracellular concentration of the neurotransmitter γ‐aminobutyric acid (GABA) is critical in determining GABAA receptor‐mediated tonic conductance in the hippocampus.
• Two GABA transporters (GAT‐1 and GAT‐3) are present in the CA3 and dentate gyrus of the hippocampus. The expression of GAT‐3 is confined to astrocytes and its role in the regulation of GABAergic neurotransmission is unclear...
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