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Objectives
To study the functional consequences of the human and rat forms of OCT2 in the presence of phenothiazines.
Methods
MDCK cells expressing human or rat OCT2 were established, and MPP+ transport was determined by uptake assays. Concentration dependency was studied for the stimulatory/inhibitory effects of phenothiazines on MPP+ transport.
Key findings
Among the 11 phenothiazines examined,...