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Recent epidemiological studies demonstrate that obesity is related to a high incidence of cognitive impairment. In the present study, cognitive behaviours in diet‐induced obese (DIO) mice fed 60% high‐fat diet for 16 weeks were compared with those in mice fed a control diet (CD) in fear‐conditioning tests including both contextual and cued elements that preferentially depend on the hippocampus and...
Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly at the postsynaptic site of retinal ON-bipolar cells. Ablation of mGluR6 in the...
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