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Purpose To investigate the blood-to-retina verapamil transport at the blood-retinal barrier (BRB). Methods EverFluor FL Verapamil (EFV) was adopted as the fluorescent probe of verapamil, and its transport across the BRB was investigated with common carotid artery infusion in rats. EFV transport at the inner and outer BRB was investigated with TR-iBRB2 cells and RPE-J cells, respectively. Results...
The elimination of histamine, an excitatory neurotransmitter, from the brain/CSF across the blood–brain barrier and blood–CSF barrier (BCSFB) was investigated using Wistar rats, which were anesthetized with pentobarbital sodium. An in vivo intracerebral microinjection study suggested that there was only partial efflux of [3H]histamine from the rat brain across the blood–brain barrier. The [3H]histamine...
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