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Cognitive decline is a devastating clinical condition, heavily correlated with age progression. In the cases of Alzheimer's disease, Parkinson's disease, and Lewy body disease, the common neuropathologies are proteinopathies and neuroinflammation. Herein, we review current lipidomics findings and conclude that brain and circulating diacylglycerols represent biomarkers of this ongoing sustained immune...
The efficacy of the amphipathic ketoamide calpain inhibitor SNJ‐1945 in attenuating calpain‐mediated degradation of the neuronal cytoskeletal protein α‐spectrin was examined in the controlled cortical impact (CCI) traumatic brain injury (TBI) model in male CF‐1 mice. Using a single early (15 min after CCI‐TBI) i.p. bolus administration of SNJ‐1945 (6.25, 12.5, 25, or 50‐mg/kg), we identified the most...
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