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Some cells, tissues and organs release 2′,3′-cAMP (a positional isomer of 3′,5′-cAMP) and convert extracellular 2′,3′-cAMP to 2′-AMP plus 3′-AMP and convert these AMPs to adenosine (called the extracellular 2′,3′-cAMP-adenosine pathway). Recent studies show that microglia have an extracellular 2′,3′-cAMP-adenosine pathway. The goal of the present study was to investigate whether the extracellular...
J. Neurochem. (2011) 118, 979–987.
AbstractMany organs express the extracellular 3′,5′‐cAMP‐adenosine pathway (conversion of extracellular 3′,5′‐cAMP to 5′‐AMP and 5′‐AMP to adenosine). Some organs release 2′,3′‐cAMP (isomer of 3′,5′‐cAMP) and convert extracellular 2′,3′‐cAMP to 2′‐ and 3′‐AMP and convert these AMPs to adenosine (extracellular 2′,3′‐cAMP‐adenosine pathway). As astrocytes and microglia...
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