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The crystal structures of both isoforms of the aminoaldehyde dehydrogenase from pea (PsAMADH) have been solved recently [Tylichováet al. (2010) J Mol Biol396, 870–882]. The characterization of the PsAMADH2 proteins, altered here by site‐directed mutagenesis, suggests that the D110 and D113 residues at the entrance to the substrate channel are required for high‐affinity binding of ω‐aminoaldehydes...
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