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A systematic method for the analysis of the hydration structure of proteins is demonstrated on the case study of lysozyme. The method utilises multiple structural data of the same protein deposited in the protein data bank. Clusters of high water occupancy are localised and characterised in terms of their interaction with protein. It is shown that they constitute a network of interconnected hydrogen...
The excitatory amino acids are cleared by a family of Na + -dependent high affinity glutamate (Glu) transporters. In vivo, two of these subtypes of transporters are expressed by glia and two are expressed by neurons. Our hypothesis is that second messenger systems controlled by mGluRs directly regulate transporter activity and regulate expression of the transporters. We will present examples...
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