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The Atomic Force Microscope using contact mode forms the image by contacting the sample surface with a sharp tip that is attached to the free end of a cantilever. While the sample is scanned horizontally the cantilever deflects. The deflection of the cantilever can be sensed among several methods. For instance, optical beam deflection where this method is often used because of it's simplicity. While...
Understanding how the mechanical properties of cells alter with disease may help with the development of novel diagnostics and treatment regimes. The emergence of tools such as the atomic force microscope (AFM) has enabled us to physically measure the mechanical properties of cells. However, suitable models for the analysis of real experimental data are either absent, or fail to provide a simple analysis...
An investigation into orientation preferences shown by actin fibres within ex-situ actin as imaged by Atomic Force Microscopy (AFM) is described. Actin is a primary cytoskeletal component and is believed to play a vital role in cell structure. Actin structure images measured by AFM were analysed using automated pre-processing steps. These steps were identical for the production of an initial binary...
There has recently been a significant growth in interest in determining the mechanical properties of living human cells. Much of this work has centred around the application of the Hertz Contact Stress model to force/displacement curves that are obtained from atomic force microscopy. However, it is widely recognised that the conventional Hertzian approach, that is based upon a linear elastic model...
All atomic force microscope (AFM) images suffer from distortions, which are principally produced by the interaction between the measured sample and the AFM tip. If the three-dimensional shape of the tip is known, the distorted image can be processed and the original surface form ‘restored’, typically by deconvolution approaches. This restored image gives a better representation of the real 3D surface...
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