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The International Conference on Harmonization (ICH) E14 document was revised in 2015 to allow concentration–corrected QT interval (C–QTc) analysis to be applied to data from early clinical pharmacology studies to exclude a small drug‐induced effect on QTc. Provided sufficiently high concentrations of the drug are obtained in the first‐in‐human (FIH) study, this approach can be used to obviate the...