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The flavivirus methyltransferase (MTase) sequentially methylates the N-7 and 2′-O positions of the viral RNA cap (GpppA-RNA→m 7 GpppA-RNA→m 7 GpppAm-RNA), using S-adenosyl-l-methionine (SAM) as a methyl donor. We report here the synthesis and biological evaluation of a series of novel nucleoside analogs. Two of these compounds can effectively and competitively inhibit the WNV MTase...
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