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Hypoxia‐induced vasoconstriction and vascular remodelling are the main pathological features of hypoxic pulmonary arterial hypertension (HPAH), and inflammation is participated in the occurrence of pulmonary vascular remodelling (PVR). Matrine is an alkaloid with the effects of anti‐inflammation, antifibrosis and antitumour. But, few studies have explored the role of matrine in regulating PVR, and...