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Over one million newborns die annually from sepsis with the highest mortality in premature and low‐birthweight infants. The inflammasome plays a central role in the regulation of innate immunity and inflammation, and is presumed to be involved in protective immunity, in large part through the caspase‐1‐dependent activation of interleukin‐1β (IL‐1β) and IL‐18. Studies in endotoxic shock, however, suggest...