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CD38 is a 45 000 molecular weight transmembrane protein that is expressed in immature and mature lymphocytes. However, the expression and function of CD38 during B‐cell differentiation in mice is poorly understood. Here, we report that CD38 is expressed from the earliest stages of B‐cell development. Pre‐pro‐B, pro‐B, pre‐B and immature B cells from murine bone marrow all stained positive for CD38...