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The interaction of a pathogen with its host cell takes place at different levels, including the bioenergetics adaptation of both the pathogen and the host cell in the course of an infection. In this regard, Mycobacterium tuberculosis infection of macrophages induces mitochondrial membrane potential (Δψm) changes and cytochrome c release, depending on the bacteria strain's virulence, and the mitochondrial...
Biological functions show rhythmic fluctuations with 24‐hr periodicity regulated by circadian proteins encoded by the so‐called ‘clock’ genes. The absence or deregulation of circadian proteins in mice leads to metabolic disorders and in vitro models have shown that the synthesis of pro‐inflammatory cytokines by macrophages follows a circadian rhythm so showing a link between circadian rhythmicity,...
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