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Evidence suggests that the acquisition of recognition memory depends upon CREB‐dependent long‐lasting changes in synaptic plasticity in the perirhinal cortex.The CREB‐responsive microRNA miR‐132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific...
The role of the CAMKK pathway in object recognition memory was investigated. Rats' performance in a preferential object recognition test was examined after local infusion into the perirhinal cortex of the CAMKK inhibitor STO‐609. STO‐609 infused either before or immediately after acquisition impaired memory tested after a 24 h but not a 20‐min delay. Memory was not impaired when STO‐609 was infused...
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