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Background and Aims
Activation of MYC and catenin beta‐1 (CTNNB1, encoding β‐catenin) can co‐occur in liver cancer, but how these oncogenes cooperate in tumorigenesis remains unclear.
Approach and Results
We generated a mouse model allowing conditional activation of MYC and WNT/β‐catenin signaling (through either β‐catenin activation or loss of APC ‐ adenomatous polyposis coli) upon expression...