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Background and Aims
Bile acids (BAs) are important regulators of metabolism and energy balance, but excess BAs cause cholestatic liver injury. The histone methyltransferase mixed‐lineage leukemia‐4 (MLL4) is a transcriptional coactivator of the BA‐sensing nuclear receptor farnesoid X receptor (FXR) and epigenetically up‐regulates FXR targets important for the regulation of BA levels, small heterodimer...
Various non-viral delivery systems for small interfering RNAs (siRNA) have been developed. Such delivery systems generally exhibit tightly formed spherical structures. While such carriers have demonstrated good transfection activity in mono-layered cell systems, effects against solid tumors are often less apparent and difficult to demonstrate, likely due to the rigid structures of the carriers, which...
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