Search results for: Shaheed Merani

Items from 1 to 19 out of 19 results

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Evaluation of serial monitoring of donor‐specific antibodies in pediatric and adult intestinal/multivisceral transplant recipients

Kelsey Klein, Megan Keck, Eric Langewisch, Shaheed Merani, more

Pediatric Transplantation > 28 > 1 > n/a - n/a

Background The study purpose was to add to limited literature assessing anti‐HLA donor‐specific antibody (DSA) appearance, clearance, specificity, and impact in intestinal/multivisceral (MV) transplant as well as the value of serial monitoring following an institutional protocol shift implementing serial monitoring. Methods This single‐center retrospective review included intestinal/MV recipients...

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Kidney injury and status 1 liver transplantation: Outcomes, kidney function, and listing for kidney transplantation

Daniel J. Cloonan, Madeline R. Cloonan, Scott G. Westphal, Leigh Anne Dageforde, more

Clinical Transplantation > 37 > 4 > n/a - n/a

Background Effects of kidney injury (KI) at the time of liver transplantation (LT) for acute liver failure (ALF) remain poorly described. We hypothesized that patients with ALF and KI who undergo LT have persistent post‐transplant KI, inferior survival, and increased rate of kidney transplantation (KT). Methods The US Scientific Registry of Transplant Recipients database was queried for patients...

article

Presentation of preclinical gastrointestinal anatomy via laparoscopic simulation

Travis L. McCumber, Justin L. Mott, Shaheed Merani, Fedja A. Rochling

Clinical Anatomy > 35 > 7 > 953 - 960

In this report, the authors examine the integration of teaching anatomical science with clinical implications in minimally invasive surgery. The authors hypothesized that implementation of integrated laparoscopic simulation during undergraduate medical education would improve student learning of anatomical structures from in situ, laparoscopic orientations; and subsequently improve student preparation...

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A North American single‐center experience with liver transplantation using thoracoabdominal normothermic regional perfusion for donation after circulatory death

Shaheed Merani, Marian Urban, John Y. Um, Alexander Maskin, more

American Journal of Transplantation > 22 > 2 > 666 - 668

article

Successful lung transplantation with graft recovered after thoracoabdominal normothermic perfusion from donor after circulatory death

Marian Urban, Anthony W. Castleberry, Nicholas W. Markin, Megan M. Chacon, more

American Journal of Transplantation > 22 > 1 > 294 - 298

Lung transplantation with lungs procured from donors after circulatory death (DCD) has been established as an alternative technique to traditional donation after brain death (DBD) with comparable outcomes. Recently, in situ thoracoabdominal normothermic regional perfusion (TA‐NRP) has emerged as a novel technique employed in the procurement of cardiac allografts after circulatory death. TA‐NRP, in...

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The impact of multi‐organ transplant allocation priority on waitlisted kidney transplant candidates

Scott G. Westphal, Eric D. Langewisch, Amanda M. Robinson, Amber R. Wilk, more

American Journal of Transplantation > 21 > 6 > 2161 - 2174

Kidney‐alone transplant (KAT) candidates may be disadvantaged by the allocation priority given to multi‐organ transplant (MOT) candidates. This study identified potential KAT candidates not receiving a given kidney offer due to its allocation for MOT. Using the Organ Procurement and Transplant Network (OPTN) database, we identified deceased donors from 2002 to 2017 who had one kidney allocated for...

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Viral enteritis in intestinal transplant recipients

Abigail M. Servais, Megan Keck, Mary Leick, David F. Mercer, more

Transplant Infectious Disease > 22 > 2 > n/a - n/a

Intestinal transplant recipients (ITR) are at high risk for infections due to the high level of immunosuppression required to prevent rejection. There are limited data regarding viral enteritis post‐intestinal transplantation. We retrospectively reviewed ITR transplanted between January 2008 and December 2016. Descriptive statistics, including mean (standard deviation) and median (range), were performed...

article

Including colon in intestinal transplantation: a focus on post‐transplant renal function – a retrospective study

Cale Ewald, Benjamin J. Swanson, Luciano Vargas, Wendy J Grant, more

Transplant International > 33 > 2 > 142 - 148

Intestinal transplant recipients experience a high rate of renal complications secondary to dehydration due to increased ostomy output. It is hypothesized that inclusion of donor colon in the intestinal allograft may improve renal function in patients without functional native colon by improving fluid absorption. A single‐center retrospective study of intestinal transplant recipients compared outcomes...

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Failure of abdominal wall closure after intestinal transplantation: Identifying high‐risk recipients

Madeline R. Cloonan, Chaeli A. Fortina, David F. Mercer, Luciano M. Vargas, more

Clinical Transplantation > 33 > 11 > n/a - n/a

Open abdomen and fascial dehiscence after intestinal transplantation increase morbidity. This study aims to identify recipient and donor factors associated with failure to achieve sustained primary closure (failed‐SPC) of the abdomen after intestinal transplant. We conducted a single‐center retrospective study of 96 intestinal transplants between 2013 and 2018. Thirty‐eight (40%) were adult patients,...

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Fortuitous benefits of living kidney donation: Diagnosis of serious medical conditions during the living donor evaluation

Arika Hoffman, Ketki Tendulkar, Shaheed Merani, Alexander Maskin, more

Clinical Transplantation > 32 > 3 > n/a - n/a

Background All living kidney donors are counseled about the possible surgical and medical risks associated with donation. Only a minority of transplant centers discuss the potential benefit of discovering undiagnosed medical conditions in the donor during evaluation, as part of their consent process. Methods We retrospectively investigated all potential living kidney donors evaluated over a 10‐year...

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Total pancreatectomy and autoislet transplant for chronic recurrent pancreatitis in a 5-year-old boy

Shaheed Merani, Rene Razzak, Tatsuya Kin, Andrea Haqq, more

Journal of Pediatric Surgery Case Reports > 2016 > 13 > C > 28-30

Childhood chronic pancreatitis is a rare disorder, which can lead to a chronically debilitating condition. The etiology of recurrent hereditary pancreatitis, which previously was classified as idiopathic, has now been attributed in certain cases to specific genetic mutations including abnormalities in the PRSS gene. We describe here the use of total pancreatectomy and autoislet transplant in a 5-year-old...

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Repeated metastasectomy in an adolescent with fibrolamellar hepatocellular carcinoma: A case report

Shaheed Merani, Gordon M. Lees

Journal of Pediatric Surgery Case Reports > 2016 > 8 > C > 3-6

The fibrolamellar variant of hepatocellular carcinoma (FL-HCC) is a primary malignancy of the liver classically identified in the non-cirrhotic liver. By virtue of the non-cirrhotic liver background, patients with FL-HCC are more likely to be selected for surgical resection as primary treatment than in classic HCC. Synchronous and metachranous metastasis of FL-HCC can be treated with either resection,...

article

Research Productivity of Residents and Surgeons With Formal Research Training

Shaheed Merani, Noah Switzer, Ahmed Kayssi, Maurice Blitz, more

Journal of Surgical Education > 2014 > 71 > 6 > 865-870

The spectrum of the surgeon-scientist ranges from a clinician who participates in the occasional research collaboration to the predominantly academic scientist with no involvement in clinical work. Training surgeon-scientists can involve resource-intense and lengthy training programs, including Masters and PhD degrees. Despite high enrollment rates in such programs, limited data exist regarding their...

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The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma

Shaheed Merani, Pietro Majno, Norman M. Kneteman, Thierry Berney, more

Journal of Hepatology > 2011 > 55 > 4 > 814-819

Liver transplantation is a recognized treatment for selected patients with hepatocellular carcinoma (HCC), but transplant criteria still need to be refined, especially in the case of more advanced or downstaged tumors.The present study investigated alpha-fetoprotein (AFP) as a predictor of outcome in 6817 patients listed with a diagnosis of HCC in the Scientific Registry of Transplant Recipients.Local...

article

Increasing tuition fees in a country with two different models of medical education

Shaheed Merani, Sonya Abdulla, Jeffrey C Kwong, Laura Rosella, more

Medical Education > 44 > 6 > 577 - 586

Medical Education 2010:44: 577–586 Context Since the early 1990s, medical school tuition fees have increased substantially in all regions of Canada except Quebec. This provides a natural opportunity to examine the effect of tuition fee increases on medical student demographics, indebtedness and financial stress. Methods We conducted a national survey of medical students in 2007. We compared...

article

Sirolimus‐based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma

Christian Toso, Shaheed Merani, David L. Bigam, A.M. James Shapiro, more

Hepatology > 51 > 4 > 1237 - 1243

Liver transplantation is an important treatment option for selected patients with nonresectable hepatocellular carcinoma (HCC). Several reports have suggested a lower risk of posttransplant tumor recurrence with the use of sirolimus and a higher one with calcineurin inhibitors, but the selection of an ideal immunosuppression protocol is still a matter of debate. The aim of this study was to define...

article

Liraglutide, a long‐acting human glucagon‐like peptide 1 analogue, improves human islet survival in culture

Christian Toso, Michael McCall, Juliet Emamaullee, Shaheed Merani, more

Transplant International > 23 > 3 > 259 - 265

The culture of human islets is associated with approximately 10–20% islet loss, occasionally preventing transplantation. Preconditioning of the islets to improve postculture yields would be of immediate benefit, with the potential to increase both the number of transplanted patients and their metabolic reserve. In this study, the effect of liraglutide, a long‐acting human glucagon‐like peptide 1 analogue,...

article

F.93. Caspase Inhibitor Therapy Promotes Tolerance Induction in Islet Transplantation

Juliet Emamaullee, Joy Davis, Christian Toso, Shaheed Merani, more

Clinical Immunology > 2008 > 127 > Supplement > S73-S74

article

Neuroimmune regulation of allergic asthma: A tripeptide regulates lung immune responses in a rat model of allergic asthma

Rene Dery, Lakshmi Puttagunta, Marina Ulanova, Deborah James, more

The Journal of Allergy and Clinical Immunology > 2002 > 109 > 1 Supplement 1 > S29

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