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Calcitonin gene–related peptide (CGRP) plays a pivotal role in migraine pathogenesis. BIBN4096BS is the first CGRP receptor antagonist available for human studies, and its efficacy in the acute treatment of migraine has been demonstrated. We investigated the ability of BIBN4096BS to inhibit human αCGRP (h-αCGRP)–induced headache and cerebral hemodynamic changes in healthy volunteers. Ten healthy...
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