Search results for: Shawn M. McClintock

Items from 1 to 20 out of 33 results

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A pilot study of magnetic seizure therapy for treatment‐resistant obsessive–compulsive disorder

Victor M. Tang, Daniel M. Blumberger, Cory R. Weissman, Julia Dimitrova, more

Depression and Anxiety > 38 > 2 > 161 - 171

Background There is growing interest in the potential of neuromodulation options in treatment‐resistant obsessive–compulsive disorder (OCD). Magnetic seizure therapy (MST), is a new treatment intervention in which generalized seizures are induced with transcranial magnetic stimulation. We conducted a pilot study to assess the efficacy and cognitive effects of MST in patients with treatment‐resistant...

article

Electroconvulsive therapy treatment responsive multimodal brain networks

Shile Qi, Christopher C. Abbott, Katherine L. Narr, Rongtao Jiang, more

Human Brain Mapping > 41 > 7 > 1775 - 1785

Electroconvulsive therapy is regarded as the most effective antidepressant treatment for severe and treatment‐resistant depressive episodes. Despite the efficacy of electroconvulsive therapy, the neurobiological underpinnings and mechanisms underlying electroconvulsive therapy induced antidepressant effects remain unclear. The objective of this investigation was to identify electroconvulsive therapy...

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Neurocognitive effects of transcranial direct current stimulation (tDCS) in unipolar and bipolar depression: Findings from an international randomized controlled trial

Shawn M. McClintock, Donel M. Martin, Sarah H. Lisanby, Angelo Alonzo, more

Depression and Anxiety > 37 > 3 > 261 - 272

Objective Transcranial direct current stimulation (tDCS) has been found to have antidepressant effects and may have beneficial neurocognitive effects. However, prior research has produced an unclear understanding of the neurocognitive effects of repeated exposure to tDCS. The study's aim was to determine the neurocognitive effects following tDCS treatment in participants with unipolar or bipolar...

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Cognitive Functioning in Late-life Depression: A Critical Review of Sociodemographic, Neurobiological, and Treatment Correlates

Vonetta M. Dotson, Sarah M. Szymkowicz, Joseph U. Kim, Shawn M. McClintock

Current Behavioral Neuroscience Reports > 2018 > 5 > 4 > 310-318

Purpose of Review Both clinical and subthreshold depression in older adults are associated with cognitive dysfunction. This review summarizes the latest literature on patterns of cognitive functioning in late-life depression (LLD), including moderators of the relationship between depression and cognitive functioning and underlying neurobiological mechanisms. Recent Findings LLD is associated with...

article

Effects of continuation electroconvulsive therapy on quality of life in elderly depressed patients: A randomized clinical trial

W. Vaughn McCall, Sarah H. Lisanby, Peter B. Rosenquist, Mary Dooley, more

Journal of Psychiatric Research > 2018 > 97 > C > 65-69

We examined whether electroconvulsive therapy (ECT) plus medications (“STABLE + PHARM” group) had superior HRQOL compared with medications alone (“PHARM” group) as continuation strategy after successful acute right unilateral ECT for major depressive disorder (MDD). We hypothesized that scores from the Medical Outcomes Study Short Form-36 (SF-36) would be higher during continuation treatment in the...

article

International randomized-controlled trial of transcranial Direct Current Stimulation in depression

Colleen K. Loo, Mustafa M. Husain, William M. McDonald, Scott Aaronson, more

Brain Stimulation > 2018 > 11 > 1 > 125-133

Evidence suggests that transcranial Direct Current Stimulation (tDCS) has antidepressant effects in unipolar depression, but there is limited information for patients with bipolar depression. Additionally, prior research suggests that brain derived neurotrophic factor (BDNF) Val66Met genotype may moderate response to tDCS.To examine tDCS efficacy in unipolar and bipolar depression and assess if BDNF...

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Cognitive enhancing effects of rTMS administered to the prefrontal cortex in patients with depression: A systematic review and meta‐analysis of individual task effects

Donel M. Martin, Shawn M. McClintock, Jane J. Forster, Tin Yan Lo, more

Depression and Anxiety > 34 > 11 > 1029 - 1039

Background Repetitive transcranial magnetic stimulation (rTMS) is an approved therapeutic treatment of major depressive disorder and has increasing clinical use throughout the world. However, it remains unclear whether an rTMS course for depression may also produce cognitive enhancement. In a recent meta‐analysis of sham‐controlled randomized controlled studies (RCTs) conducted in patients with neuropsychiatric...

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Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients

W. Vaughn McCall, Sarah H. Lisanby, Peter B. Rosenquist, Mary Dooley, more

Journal of Affective Disorders > 2017 > 209 > C > 39-45

Patients with Major Depressive Disorder (MDD) referred for electroconvulsive therapy (ECT) have poorer Health Related Quality of Life (HRQOL), compared with other patients with MDD, but ECT is associated with significant and durable improvement in HRQOL. However, no prior research has focused exclusively on elderly patients with MDD receiving ECT.HRQOL data from 240 depressed patients over the age...

article

Study design and methodology for a multicentre, randomised controlled trial of transcranial direct current stimulation as a treatment for unipolar and bipolar depression

Angelo Alonzo, Scott Aaronson, Marom Bikson, Mustafa Husain, more

Contemporary Clinical Trials > 2016 > 51 > C > 65-71

Transcranial Direct Current Stimulation (tDCS) is a new, non-invasive neuromodulation approach for treating depression that has shown promising efficacy. The aim of this trial was to conduct the first international, multicentre randomised controlled trial of tDCS as a treatment for unipolar and bipolar depression. The study recruited 120 participants across 6 sites in the USA and Australia. Participants...

article

Supporting the careers of junior investigator scientists in geriatric psychoneuropharmacology

Sara Weisenbach, Shawn M. McClintock

International Journal of Geriatric Psychiatry > 31 > 10 > 1095 - 1096

article

Does Therapeutic Repetitive Transcranial Magnetic Stimulation Cause Cognitive Enhancing Effects in Patients with Neuropsychiatric Conditions? A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Donel M. Martin, Shawn M. McClintock, Jane Forster, Colleen K. Loo

Neuropsychology Review > 2016 > 26 > 3 > 295-309

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic intervention for neuropsychiatric illnesses and has demonstrated efficacy for treatment of major depression. However, an unresolved question is whether a course of rTMS treatment results in effects on cognitive functioning. In this systematic review and meta-analysis we aimed to quantitatively determine whether...

article

Use of the Montreal Cognitive Assessment and Alzheimer's Disease‐8 as cognitive screening measures in Parkinson's disease

Daniel S. Brown, Ira H. Bernstein, Shawn M. McClintock, C. Munro Cullum, more

International Journal of Geriatric Psychiatry > 31 > 3 > 264 - 272

ObjectiveTo examine the sensitivity and specificity of the Montreal Cognitive Assessment (MoCA), a brief cognitive screening measure previously validated for use in Parkinson's disease (PD), and Alzheimer's Disease‐8 (AD8), an eight‐item informant report used to screen for dementia, but not yet validated for use in PD, to identify cognitive impairment in a sample of 111 patients with PD. MethodsCognitive...

article

TrkB activation by 7, 8‐dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease

Lei Gao, Mi Tian, Hong‐Yun Zhao, Qian‐Qian Xu, more

Journal of Neurochemistry > 136 > 3 > 620 - 636

We recently demonstrated that activation of tyrosine receptor kinase B (TrkB) by 7, 8‐dihydroxyflavone (7, 8‐DHF), the selective TrkB agonist, increased surface alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) receptors (AMPARs) AMPA receptor subunit GluR1 (GluA1) subunit expression at the synapses of Fragile X Syndrome mutant mice. This present study investigated the effects of 7,...

article

Handwriting fluency and visuospatial generativity at primary school

Paolo Stievano, Silvia Michetti, Shawn M. McClintock, Gabriel Levi, more

Reading and Writing > 2016 > 29 > 7 > 1497-1510

Handwriting is a complex activity that involves continuous interaction between lowerlevel perceptual-motor and higher-level cognitive processes. All handwriting models describe involvement of executive functions (EF) in handwriting development. Particular EF domains associated with handwriting include maintenance of information in working memory, inhibition of prepotent responses, and shifting and...

article

The Effect of Cognitive Functioning on Treatment Attendance and Adherence in Comorbid Bipolar Disorder and Cocaine Dependence

Colleen S. Fagan, Thomas J. Carmody, Shawn M. McClintock, Alina Suris, more

Journal of Substance Abuse Treatment > 2015 > 49 > Complete > 15-20

Although bipolar disorder and substance dependence are both associated with treatment non-adherence and cognitive impairment, no studies have investigated relationships between treatment adherence and cognitive functioning in this population. As part of a clinical trial, baseline performance on two neuropsychological tests in 120 outpatients with bipolar disorder and cocaine dependence was used to...

article

7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome

Mi Tian, Yan Zeng, Yilan Hu, Xiuxue Yuan, more

Neuropharmacology > 2015 > 89 > Complete > 43-53

Fragile X syndrome (FXS) is characterized by immature dendritic spine architectures and cognitive impairment. 7, 8-Dihydroxyflavone (7, 8-DHF) has recently been identified as a high affinity tropomyosin receptor kinase B (TrkB) agonist. The purpose of this paper was to examine the utility of 7, 8-DHF as an effective pharmacotherapeutic agent that targets dendritic pathology and cognitive impairments...

article

Neuromodulation for mood and memory: from the engineering bench to the patient bedside

Zhi-De Deng, Shawn M McClintock, Nicodemus E Oey, Bruce Luber, more

Current Opinion in Neurobiology > 2015 > 30 > Complete > 38-43

Brain stimulation, in the form of electroconvulsive therapy (ECT), has long been a gold standard treatment for depression, but today, the field of neuromodulation is rapidly changing with the advent of newer and more precise tools to alter neuroplasticity and to treat brain-based disorders. Now there are new means to induce focal seizures, as with magnetic seizure therapy (MST), or modifications to...

article

Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia

Deepa Acharya, David G. Harper, Eric D. Achtyes, Stephen J. Seiner, more

International Journal of Geriatric Psychiatry > 30 > 3 > 265 - 273

ObjectiveAgitation and aggression are among the most frequent and disruptive behavioral complications of dementia that contribute to increased cost of care, hospitalization, caregiver burden, and risk of premature institutionalization. This current study examined the safety and efficacy of electroconvulsive therapy (ECT) as a treatment for behavioral disturbances in dementia. We hypothesized that...

article

NEUROPSYCHOLOGICAL FUNCTION BEFORE AND AFTER SUBCALLOSAL CINGULATE DEEP BRAIN STIMULATION IN PATIENTS WITH TREATMENT‐RESISTANT DEPRESSION

Jared L. Moreines, Shawn M. McClintock, Mary E. Kelley, Paul E. Holtzheimer, more

Depression and Anxiety > 31 > 8 > 690 - 698

BackgroundTreatment‐resistant depression (TRD) is a pervasive and difficult to treat condition for which deep brain stimulation (DBS) of the subcallosal cingulate white matter (SCCwm) is an emerging therapeutic option. However, neuropsychological safety data for this novel treatment have only been published for a small number of subjects. Moreover, little is known regarding the neuropsychological...

article

Differential Effect of Three Electrode Placements in Older vs Younger Patients with Severe Depression treated with Electroconvulsive Therapy (ECT)

Sohag Sanghani, Georgios Petrides, Rebecca Knapp, Mustafa Husain, more

The American Journal of Geriatric Psychiatry > 2014 > 22 > 3(S) > S114

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Search results for: Shawn M. McClintock

A pilot study of magnetic seizure therapy for treatment‐resistant obsessive–compulsive disorder

Electroconvulsive therapy treatment responsive multimodal brain networks

Neurocognitive effects of transcranial direct current stimulation (tDCS) in unipolar and bipolar depression: Findings from an international randomized controlled trial

Cognitive Functioning in Late-life Depression: A Critical Review of Sociodemographic, Neurobiological, and Treatment Correlates

Effects of continuation electroconvulsive therapy on quality of life in elderly depressed patients: A randomized clinical trial

International randomized-controlled trial of transcranial Direct Current Stimulation in depression

Cognitive enhancing effects of rTMS administered to the prefrontal cortex in patients with depression: A systematic review and meta‐analysis of individual task effects

Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients

Study design and methodology for a multicentre, randomised controlled trial of transcranial direct current stimulation as a treatment for unipolar and bipolar depression

Supporting the careers of junior investigator scientists in geriatric psychoneuropharmacology

Does Therapeutic Repetitive Transcranial Magnetic Stimulation Cause Cognitive Enhancing Effects in Patients with Neuropsychiatric Conditions? A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Use of the Montreal Cognitive Assessment and Alzheimer's Disease‐8 as cognitive screening measures in Parkinson's disease

TrkB activation by 7, 8‐dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease

Handwriting fluency and visuospatial generativity at primary school

The Effect of Cognitive Functioning on Treatment Attendance and Adherence in Comorbid Bipolar Disorder and Cocaine Dependence

7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome

Neuromodulation for mood and memory: from the engineering bench to the patient bedside

Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia

NEUROPSYCHOLOGICAL FUNCTION BEFORE AND AFTER SUBCALLOSAL CINGULATE DEEP BRAIN STIMULATION IN PATIENTS WITH TREATMENT‐RESISTANT DEPRESSION

Differential Effect of Three Electrode Placements in Older vs Younger Patients with Severe Depression treated with Electroconvulsive Therapy (ECT)

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