Search results for: Ruizhen Chen

Items from 1 to 20 out of 45 results

article

Left bundle branch area pacing is superior to right ventricular septum pacing concerning depolarization‐repolarization reserve

Jingfeng Wang, Yixiu Liang, Wei Wang, Xueying Chen, more

Journal of Cardiovascular Electrophysiology > 31 > 1 > 313 - 322

Introduction Left bundle branch area pacing (LBBAP) has recently been reported to be a new physiological pacing strategy with clinical feasibility and safety. The present study aims to investigate depolarization‐repolarization measures including QT interval, QT dispersion (QTD), and T_peak‐end interval (T_pT_e) in this novel LBBAP strategy. Methods and Results A total of 131 pacing‐indicated patients...

article

microRNA‐34a aggravates coxsackievirus B3‐induced apoptosis of cardiomyocytes through the SIRT1‐p53 pathway

Dehua Jiang, Minghui Li, Ying Yu, Hui Shi, more

Journal of Medical Virology > 91 > 9 > 1643 - 1651

Viral myocarditis is inflammation of the myocardium mainly caused by a viral infection, and coxsackievirus B3 (CVB3) infection is one of the most common. It is well known that cardiomyocyte apoptosis is involved in the pathogenesis of viral myocarditis. microRNAs (miRNAs, miRs) are endogenous noncoding oligoribonucleotides involved in various pathological conditions, and miR‐34a is one of the miRNAs...

article

FTY720 alleviates coxsackievirus B3‐induced myocarditis and inhibits viral replication through regulating sphingosine 1‐phosphate receptors and AKT/caspase‐3 pathways

Xinggang Wang, Minghui Li, Ying Yu, Guijian Liu, more

Journal of Cellular Physiology > 234 > 10 > 18029 - 18040

Fingolimod (FTY720) after phosphorylation, as the ligand of sphingosine 1‐phosphate receptors (S1PRs), plays an important role in cell proliferation and differentiation. In this article, FTY720 in the treatment of coxsackievirus B3 (CVB3)‐induced viral myocarditis was closely related to apoptosis and AKT/caspase‐3 apoptotic pathways. We found that CVB3 inhibited myocardial apoptosis at the early stage...

article

Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion

Ting Cao, Shuai Fan, Dong Zheng, Grace Wang, more

Basic Research in Cardiology > 2019 > 114 > 3 > 1-15

We and others have reported that calpain-1 was increased in myocardial mitochondria from various animal models of heart disease. This study investigated whether constitutive up-regulation of calpain-1 restricted to mitochondria induced myocardial injury and heart failure and, if so, whether these phenotypes could be rescued by selective inhibition of mitochondrial superoxide production. Transgenic...

article

LAP⁺ Treg is a better biomarker than total Treg in viral myocarditis

Xinggang Wang, Junbo Ge, Ruizhen Chen

Journal of Medical Virology > 91 > 5 > 886 - 889

Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP⁺ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP⁺ Treg out of CD4⁺ cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg...

article

Electrocardiographic parameters effectively predict ventricular tachycardia/fibrillation in acute phase and abnormal cardiac function in chronic phase of ST‐segment elevation myocardial infarction

Ziqing Yu, Zhangwei Chen, Yuan Wu, Ruizhen Chen, more

Journal of Cardiovascular Electrophysiology > 29 > 5 > 756 - 766

Background Abnormal cardiac repolarization is closely associated with ventricular tachycardia/ventricular fibrillation (VT/VF). Myocardial ischemia and infarction aggravate cardiac repolarization dispersion, and VT/VF could be lethal in the early stage of ST‐segment elevation myocardial infarction (STEMI). Unfortunately, VT/VF cannot be effectively predicted in current clinical practice. The present...

article

Comparison of single-coil lead versus dual-coil lead of implantable cardioverter defibrillator on lead-related venous complications in a canine model

Ziqing Yu, Yuan Wu, Shengmei Qin, Jingfeng Wang, more

Journal of Interventional Cardiac Electrophysiology > 2018 > 52 > 2 > 195-201

Purpose Dual- coil lead (DCL) of implantable cardioverter defibrillator (ICD) is preferred clinically in patients. However, it is related to higher risk of venous stenosis and thrombosis. The present study was done to compare the fibrosis and extraction of the leads between the single-coil lead (SCL) and DCL in animal models. Methods This was a chronic animal study with a follow-up duration of 6...

article

Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells

Xinggang Wang, Yong Yu, Minghui Li, Ying Yu, more

Experimental and Molecular Pathology > 2017 > 103 > 2 > 210-217

Sphingosine 1-phosphate (S1P), via binding to its specific receptors of S1PR1, participates in the regulation of both innate and adaptive immunity. Recent reports have identified S1P as a messenger mediating inflammation. However, roles of S1P in Coxsackievirus B3 (CVB3)-induced myocarditis were largely unknown. Here, we investigated the effect of S1P treatment on CVB3-induced myocarditis in vivo...

article

Integrative and quantitive evaluation of the efficacy of his bundle related pacing in comparison with conventional right ventricular pacing: a meta-analysis

Ziqing Yu, Ruizhen Chen, Yangang Su, Xueying Chen, more

BMC Cardiovascular Disorders > 2017 > 17 > 1 > 1-13

Background Long-term RVP could bring adverse problems to cardiac electro-mechanics and result in inter- and intra-ventricular asynchrony, impaired labor force, and aggravation of cardiac function. HBRP including direct His bundle pacing and para-His bundle pacing was regarded as a novel physiological pacing pattern to avoid devastating cardiac function. This synthetic study was conducted to integratively...

article

Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway

Lili Xu, Dengfeng Cheng, Zheyong Huang, Suling Ding, more

Atherosclerosis > 2017 > 263 > C > 42-52

The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b⁺Gr-1⁺ myeloid cells that play a critical role in infection, inflammation and tumorigenesis. The aim of this study was to explore the role of Hdc-expressing CD11b⁺ myeloid cells or histamine in atherogenesis.Hdc-EGFP bacterial artificial chromosome (BAC) transgenic reporter mice (Hdc-EGFP) were used to...

article

Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis

Minghui Li, Yangang Su, Yong Yu, Ying Yu, more

International Journal of Cardiology > 2016 > 221 > C > 1123-1131

Viral myocarditis (VMC) treatment has long been lacking of effective methods. Our former studies indicated roles of calpain in VMC pathogenesis. This study aimed at verifying the potential of calpain in Coxsackievirus B3 (CVB3)-induced myocarditis treatment.A transgenic mouse overexpressing the endogenous calpain inhibitor, calpastatin, was introduced in the study. VMC mouse model was established...

article

Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway

Ying Yu, Yong Yu, Ming Liu, Peng Yu, more

SpringerPlus > 2016 > 5 > 1 > 1-10

Inflammation plays important roles in the pathogenesis of coxsackievirus B3 (CVB3)-induced acute viral myocarditis (AVMC). Ethyl pyruvate (EP) has been shown to be an anti-inflammatory agent. High mobility group box 1 (HMGB1)/receptor for advanced glycation end product (RAGE)/nuclear factor (NF)-ΚB pathway has close relation with inflammatory responses. Here, we investigated the effects of EP on CVB3-induced...

article

Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice

Dong Zheng, Jian Ma, Yong Yu, Minghui Li, more

Diabetologia > 2015 > 58 > 8 > 1949-1958

Aims/hypothesis MicroRNAs (miRs) have been suggested as potential therapeutic targets for heart diseases. Inhibition of miR-195 prevents apoptosis in cardiomyocytes stimulated with palmitate and transgenic overexpression of miR-195 induces cardiac hypertrophy and heart failure. We investigated whether silencing of miR-195 reduces diabetic cardiomyopathy in a mouse model of streptozotocin (STZ)-induced...

chapter

Design of a 440GHz Sub-harmonic GaAs Schottky diode mixer

Ruizhen Chen, Bo Zhang, Yong Fan

2014 IEEE International Conference on Electron Devices and Solid-State Circuits > 1 - 2

2014 IEEE International Conference on Electron Devices and Solid-State Circuits (EDSSC)

This paper present the design and optimization of a 440GHz sub-harmonic mixer based on an anti-parallel pair of planar GaAs Schottky diodes which is flip-chipped onto the 100 um thick quartz substrate. Simulation of the sub-harmonic mixer exhibits that the double side band (DSB) conversion loss is below 8.3 dB over the range of 420–460GHz. The optimized conversion loss of the 440GHz mixer is 7.6 dB...

article

Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: An in vitro study in H9c2 cells

Minghui Li, Xinggang Wang, Yong Yu, Ying Yu, more

Virus Research > 2014 > 179 > Complete > 177-186

Calpain is a family of neutral cysteine proteinase involved in many physiological and pathological processes including virus replication, autophagy and apoptosis. Previous study has indicated the involvement of calpain in pathogenesis of coxsackievirus B3 (CVB3)-induced myocarditis. Besides, many studies demonstrated that host cell autophagy and apoptosis mechanisms participate in virus life cycle...

article

Influence of cardioversion on asymptomatic cerebral lesions following atrial fibrillation ablation

Guijian Liu, Ruizhen Chen, Wenqing Zhu, Kuan Cheng, more

Journal of Interventional Cardiac Electrophysiology > 2014 > 40 > 2 > 129-136

Purpose Asymptomatic cerebral lesions detected by diffusion-weighted magnetic resonance imaging (MRI) following atrial fibrillation (AF) ablation were reported in recent years. It was reported that cardioversion during the procedure of AF ablation was one independent risk factor of asymptomatic cerebral lesions. However, in some studies, the similar association between asymptomatic cerebral lesions...

article

A problem in an article called “Immunoregulatory effects of α-GalCer in a murine model of autoimmune myocarditis” published in Experimental and Molecular Pathology 91 (2011) 636–642

Xinggang Wang, Ruizhen Chen

Experimental and Molecular Pathology > 2013 > 95 > 3 > 393

article

Preexposure to PM2.5 exacerbates acute viral myocarditis associated with Th17 cell

Yuquan Xie, Xian Zhang, Zhenyong Tian, Rongfang Jiang, more

International Journal of Cardiology > 2013 > 168 > 4 > 3837-3845

It is increasingly recognized that exposure to ambient fine particles (PM _2.5 ) is a risk factor for the development of cardiovascular events. This study was to explore the link between PM _2.5 exposure and viral myocarditis in the functional mechanism of Th17 cells.Male BALB/c mice were administered an intratracheal (i.t.) instillation of 10mg/kg b.w. PM _2.5 particles. Twenty-four...

article

Initial weight and virus dose: two factors affecting the onset of acute coxsackievirus B3 myocarditis in C57BL/6 mouse—a histopathology-based study

Minghui Li, Xinggang Wang, Yuquan Xie, Yeqing Xie, more

Cardiovascular Pathology > 2013 > 22 > 1 > 96-101

C57BL/6 mice have been considered resistant to cardiotropic coxsackievirus B3 (CVB3)-induced myocarditis. However, establishment of viral myocarditis model in C57BL/6 mouse is still a necessity. Here, we discuss the effects of mouse initial body weight and different virus inoculation doses on the onset of acute viral myocarditis in C57BL/6 mouse.According to initial body weight, mice were grouped...

article

Impact of Expression of EMP Enzymes on Glucose Metabolism in Zymomonas mobilis

Rachel Ruizhen Chen, Manoj Agrawal, Zichao Mao

Applied Biochemistry and Biotechnology > 2013 > 170 > 4 > 805-818

Zymomonas mobilis is the only known microorganism that utilizes the Entner–Doudoroff (ED) pathway anaerobically. In this work, we investigated whether the overexpression of a phosphofructokinase (PFK), the only missing Embden–Meyerhof–Parnas (EMP) pathway enzyme, could establish the pathway in this organism. Introduction of a pyrophosphate-dependent PFK, along with co-expression of homologous fructose-1,6-bisphosphate...

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Search results for: Ruizhen Chen

Left bundle branch area pacing is superior to right ventricular septum pacing concerning depolarization‐repolarization reserve

microRNA‐34a aggravates coxsackievirus B3‐induced apoptosis of cardiomyocytes through the SIRT1‐p53 pathway

FTY720 alleviates coxsackievirus B3‐induced myocarditis and inhibits viral replication through regulating sphingosine 1‐phosphate receptors and AKT/caspase‐3 pathways

Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion

LAP⁺ Treg is a better biomarker than total Treg in viral myocarditis

Electrocardiographic parameters effectively predict ventricular tachycardia/fibrillation in acute phase and abnormal cardiac function in chronic phase of ST‐segment elevation myocardial infarction

Comparison of single-coil lead versus dual-coil lead of implantable cardioverter defibrillator on lead-related venous complications in a canine model

Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells

Integrative and quantitive evaluation of the efficacy of his bundle related pacing in comparison with conventional right ventricular pacing: a meta-analysis

Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway

Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis

Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway

Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice

Design of a 440GHz Sub-harmonic GaAs Schottky diode mixer

Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: An in vitro study in H9c2 cells

Influence of cardioversion on asymptomatic cerebral lesions following atrial fibrillation ablation

A problem in an article called “Immunoregulatory effects of α-GalCer in a murine model of autoimmune myocarditis” published in Experimental and Molecular Pathology 91 (2011) 636–642

Preexposure to PM2.5 exacerbates acute viral myocarditis associated with Th17 cell

Initial weight and virus dose: two factors affecting the onset of acute coxsackievirus B3 myocarditis in C57BL/6 mouse—a histopathology-based study

Impact of Expression of EMP Enzymes on Glucose Metabolism in Zymomonas mobilis

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