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AbstractIn epilepsy, the GABA and glutamate balance may be disrupted and a transient decrease in extracellular calcium occurs before and during a seizure. Flow Cytometry based fluorescence activated particle sorting experiments quantified synaptosomes from human neocortical tissue, from both epileptic and non‐epileptic patients (27.7% vs. 36.9% GABAergic synaptosomes, respectively). Transporter‐mediated...
To learn whether epileptic seizures in Rasmussen encephalitis (RE) may be promoted by insufficient γ‐aminobutyric acid (GABA) release. 3H‐GABA was released from neocortical synaptosomes through transporter reversal following intrasynaptosomal Na+ accumulation by veratridine that prevents inactivation of Na+ channels. Tissues of three RE patients were compared with those of nine non‐RE. In RE, the...
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