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BackgroundThis study aimed to investigate the effect of a single dose of the mGluR5‐antagonist AZD9272 on electrically induced pain, central sensitization and axon reflex flare.
MethodsThis was a randomized, double‐blind, placebo‐controlled crossover study. Twenty‐five healthy male volunteers received a single oral dose of AZD9272 or placebo on two occasions separated by 10–20 days. Electrical stimulation...
Assess the efficacy of once-daily extended release quetiapine fumarate (quetiapine XR) in patients with schizophrenia and depressive symptoms.12-week, multi-centre, open-label study in adult patients with schizophrenia (D1444C00147). Patients were cross titrated to quetiapine XR over three days (Day 1: 300 mg; Day 2: 600 mg; Days 3-84: 400-800 mg/day [flexible dosing]). Two patient subsets: high depression...
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