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NK cells are the main cells of the innate immune system that produce IFN‐γ, and they express this cytokine at early stages of maturation in response to cytokine stimulation. Conversely, acquisition of IFN‐γ‐competence in CD4+T helper cells requires a differentiation process from naïve toward type 1 (Th1) cells, which is associated with epigenetic remodeling at the IFNG locus. In the present study,...
Many studies have examined pathways controlling effector T cell differentiation, but less is known about the fate of individual CD8 + T cells during infection. Here, we examine the antiviral and antibacterial responses of single CD8 + T cells from the polyclonal repertoire. The progeny of naive clonal CD8 + T cells displayed unique profiles of differentiation based on extrinsic...
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