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Objectives
The presence of targeted therapy, Enasidenib, for IDH2‐mutated AML underscores the importance of understanding the clonal dynamics of IDH2 mutations, which has not been elucidated. In the largest study of IDH2 clonal dynamics, we detail the IDH2‐evolutionary patterns and their clinical significance.
Methods
We analyzed ~6000 patients with NGS results to identify 120 AML patients with...