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Sphingosine-1-phosphate (S1P) receptors mediate transactivation of epidermal growth factor receptor (EGFR) by estrogen (E2). Here we report that the amount of intracellular EGFR remains elevated after stimulation of MCF-7 cells with E2 and S1P, although membrane-localized EGFR and S1P3 receptors are quickly internalized. Co-localization of internalized EGFR and LAMP-2 was lower in cells treated with...
Diabet. Med. 29, e249–e254 (2012)
AbstractAims To evaluate the effectiveness of a family‐centred group education programme, in adolescents with Type 1 diabetes.Methods Three hundred and five adolescents with Type 1 diabetes; age 13.1 ± 1.9 years, diabetes duration 5.6 ± 3.3 years, BMI 20.9 ± 3.7 kg/m2, HbA1c 78 ± 6 mmol/mol (9.3 ± 1.9%) were randomly allocated to the Families and Adolescents Communication...
Recent studies have clearly demonstrated that estrogen signaling is not limited by the canonical ‘genomic’ pathway. Estrogens have been shown to interact with multiple cytoplasmic signaling networks including that of growth factors, cytokines, and the most recently recognised participants, sphingolipids. Sphingosine kinase (SphK), a key enzyme in metabolic pathways of sphingolipids, plays an important...
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