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Cellular signaling is largely dependent on the presence, that is, assembly/disassembly, of supramolecular complexes. Postsynaptic density protein, Discs‐large, Zona occludens (PDZ) domains play important roles in the assembly of various signaling complexes. Syntenin‐2 (S2) is a PDZ protein that interacts with nuclear phosphatidylinositol 4,5‐bisphosphate (PIP2). Although nuclear lipids emerge as key...