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BACKGROUNDProteasome inhibitors and mammalian target of rapamycin inhibitors each have activity in various B‐cell malignancies and affect distinct cellular pathways. Their combination has demonstrated synergy in vitro and in mouse models.
METHODSThe authors conducted a single‐arm, phase 2 trial of combined temsirolimus and bortezomib in patients with relapsed and refractory B‐cell non‐Hodgkin lymphoma...