Search results for: Jaffer A. Ajani

Items from 1 to 20 out of 183 results

article

Concurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival

Alisa N. Blumenthaler, Timothy E. Newhook, Naruhiko Ikoma, Jeannelyn S. Estrella, more

Journal of Surgical Oncology > 123 > 4 > 911 - 922

Background and Objectives We sought to evaluate the impact of lymphovascular invasion (LVI) and perineural invasion (PNI) on survival outcomes in gastric cancer patients treated with preoperative therapy. Methods Patients with gastric cancer treated with preoperative therapy and potentially curative resection were stratified according to the presence of LVI, PNI, or both. Kaplan–Meier and Cox regression...

article

Relationship between initial management strategy and survival in patients with gastric outlet obstruction due to gastric cancer

Alisa N. Blumenthaler, Naruhiko Ikoma, Mariela Blum, Prajnan Das, more

Journal of Surgical Oncology > 122 > 7 > 1373 - 1382

Background The optimal management of gastric outlet obstruction (GOO) due to gastric cancer (GC) is unclear. We examined the relationships between clinical and management variables and outcomes in patients with GC having GOO. Methods The GOO management and clinical course were reviewed in patients with GC and GOO. Cox regression and Kaplan‐Meier analyses were used to identify variables predictive...

article

Impact of tumor regression grade on recurrence after preoperative chemoradiation and gastrectomy for gastric cancer

Alexander P. Stark, Jeannelyn S. Estrella, Yi‐Ju Chiang, Prajnan Das, more

Journal of Surgical Oncology > 122 > 3 > 422 - 432

Background and Objectives It is unknown whether the degree of response to preoperative therapy correlates with locoregional recurrence (LR) or distant recurrence (DR) after resection of gastric cancer. Methods Patients who underwent resection of gastric adenocarcinoma following chemotherapy and chemoradiation (1995‐2015) were reviewed. The tumor regression grade (TRG) was defined by the percentage...

article

The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective

Yan Xu, Shumei Song, Zhenning Wang, Jaffer A. Ajani

Cell Communication and Signaling > 2019 > 17 > 1 > 1-10

Patients with advanced gastric cancer usually have a poor prognosis and limited therapeutic options. Overcoming this challenge requires novel targets and effective drugs. The Hedgehog (Hh) signaling pathway plays a crucial role in the development of the gastrointestinal tract and maintenance of the physiologic function of the stomach. Aberrantly activated Hh signaling is implicated in carcinogenesis...

article

Gastric cancer in the remnant stomach after pancreaticoduodenectomy: A case series

Keita Sonoda, Rashmi T. Samdani, Naruhiko Ikoma, Dilsa Mizrak Kaya, more

Journal of Surgical Oncology > 120 > 7 > 1137 - 1141

Background Gastric cancer (GC) occasionally develops in the remnant stomach following pancreaticoduodenectomy (PD). In those who have undergone PD for adenocarcinoma, however, the interval and frequency of anastomotic GC are unknown. Methods We searched our institutional database for patients who had undergone PD for adenocarcinoma and subsequently developed GC between 1994 and 2018 and found six...

article

LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma

Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, more

Molecular Cancer > 2019 > 18 > 1 > 1-15

Background PVT1 has emerged as an oncogene in many tumor types. However, its role in Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unknown. The aim of this study was to assess the role of PVT1 in BE/EAC progression and uncover its therapeutic value against EAC. Methods PVT1 expression was assessed by qPCR in normal, BE, and EAC tissues and statistical analysis was performed to...

article

Characteristics and Survival of Gastric Cancer Patients with Pathologic Complete Response to Preoperative Therapy

Alexander P. Stark, Naruhiko Ikoma, Yi-Ju Chiang, Jeannelyn S. Estrella, more

Annals of Surgical Oncology > 2019 > 26 > 11 > 3602-3610

Background Pathologic complete response of a primary tumor (ypT0) after preoperative therapy is associated with improved overall survival (OS). However, whether other variables are associated with outcome for gastric cancer patients with ypT0 status is unknown. Methods This study reviewed an institutional database of patients who underwent resection of gastric or gastroesophageal adenocarcinoma...

article

The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumors

Yuki Koga, Masaaki Iwatsuki, Kohei Yamashita, Yuki Kiyozumi, more

Gastric Cancer > 2019 > 22 > 6 > 1100-1108

Background Few reliable prognostic markers have been established despite elucidation of the molecular mechanisms of gastrointestinal stromal tumor (GIST) development. We evaluated F-box and WD repeat domain-containing 7 (FBXW7), a cell-cycle-regulating and tumor suppressor, in GISTs. We aimed to determine the clinical relevance of FBXW7 in GISTs and characterize the molecular mechanism of FBXW7 in...

article

Biomarker analysis of the GATSBY study of trastuzumab emtansine versus a taxane in previously treated HER2-positive advanced gastric/gastroesophageal junction cancer

Manish A. Shah, Yoon-Koo Kang, Peter C. Thuss-Patience, Atsushi Ohtsu, more

Gastric Cancer > 2019 > 22 > 4 > 803-816

Background Prespecified exploratory biomarker analyses of the phase II/III GATSBY study (NCT01641939) assessed whether patient subgroups experienced a survival benefit from trastuzumab emtansine (T-DM1) versus taxane therapy, and to advance understanding of HER2-positive advanced gastric/gastroesophageal junction cancer (AGC) disease biology. Methods Adults with HER2-positive AGC whose disease progressed...

article

Laparoscopic Hyperthermic Intraperitoneal Chemotherapy is Safe for Patients with Peritoneal Metastases from Gastric Cancer and May Lead to Gastrectomy

Timothy E. Newhook, Annamaria Agnes, Mariela Blum, Jeannelyn S. Estrella, more

Annals of Surgical Oncology > 2019 > 26 > 5 > 1394-1400

Background Laparoscopic hyperthermic intraperitoneal chemotherapy (LS-HIPEC) is a novel strategy for patients with gastric adenocarcinoma (GA) metastatic to the peritoneum. We evaluated the safety profile of LS-HIPEC for patients with positive peritoneal cytology (PPC) or carcinomatosis from GA. Methods Outcomes were reviewed of patients with stage IV GA with peritoneal involvement who received...

article

Targeting Angiogenesis in Colorectal Carcinoma

Anthony Lopez, Kazuto Harada, Maria Vasilakopoulou, Namita Shanbhag, more

Drugs > 2019 > 79 > 1 > 63-74

Neo-angiogenesis plays a key role in colorectal cancer, with the vascular endothelial growth factor family proteins and their receptors in particular triggering multiple signaling networks that result in endothelial cell survival, migration, mitogenesis, differentiation, and vascular permeability. Anti-angiogenic therapies have improved colorectal cancer prognosis within the past 15 years. Bevacizumab...

article

Cancer stem cells in esophageal cancer and response to therapy

Kazuto Harada, Melissa Pool Pizzi, Hideo Baba, Namita D. Shanbhag, more

Cancer > 124 > 20 > 3962 - 3964

article

The ypT category does not impact overall survival in node negative gastric cancer

Naruhiko Ikoma, Wayne L. Hofstetter, Jeannelyn S. Estrella, Prajnan Das, more

Journal of Surgical Oncology > 117 > 8 > 1721 - 1728

Background Although the eighth‐edition American Joint Committee on Cancer (AJCC) gastric cancer staging system created ypTNM staging for patients who underwent preoperative therapy, the ideal ypTNM grouping is unknown. We sought to investigate risk factors for OS in ypT0‐3N0M0 gastric cancer. Methods From an institutional database of The University of Texas MD Anderson Cancer Center and the National...

article

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

André Kahles, Kjong-Van Lehmann, Nora C. Toussaint, Matthias Hüser, more

Cancer Cell > 2018 > 34 > 2 > 211-224.e6

Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alternative splicing events than normal samples. Association analysis of somatic variants with alternative splicing events confirmed known trans associations...

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

Matthew H. Bailey, Collin Tokheim, Eduard Porta-Pardo, Sohini Sengupta, more

Cell > 2018 > 174 > 4 > 1034-1035

article

Surgeon Assessment of Gastric Cancer Lymph Node Specimens with a Video of Technique

Naruhiko Ikoma, Jeannelyn S. Estrella, Wayne L. Hofstetter, Jaffer A. Ajani, more

Journal of Gastrointestinal Surgery > 2018 > 22 > 11 > 2013-2019

Introduction In the majority of US institutions, gastrectomy specimens are sent for pathologic examination without surgeon assessment or standardized technique of lymph node (LN) assessment for gastric cancer. We conducted a quality improvement project at a US cancer center utilizing surgeon assessment of gastric LNs, and created a video to illustrate a technique of standardized lymph node assessment...

article

Severe lymphopenia during neoadjuvant chemoradiation for esophageal cancer: A propensity matched analysis of the relative risk of proton versus photon-based radiation therapy

Yutaka Shiraishi, Penny Fang, Cai Xu, Juhee Song, more

Radiotherapy and Oncology > 2018 > 128 > 1 > 154-160

Circulating lymphocytes are exquisitely sensitive to radiation exposure, even to low scattered doses which can vary drastically between radiation modalities. We compared the relative risk of radiation-induced lymphopenia between intensity modulated radiation therapy (IMRT) or proton beam therapy (PBT) in esophageal cancer (EC) patients undergoing neoadjuvant chemoradiation therapy (nCRT).EC patients...

article

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Christopher J. Ricketts, Aguirre A. De Cubas, Huihui Fan, Christof C. Smith, more

Cell Reports > 2018 > 23 > 12 > 3698

article

Nodal Downstaging in Gastric Cancer Patients: Promising Survival if ypN0 is Achieved

Naruhiko Ikoma, Jeannelyn S. Estrella, Wayne Hofstetter, Prajnan Das, more

Annals of Surgical Oncology > 2018 > 25 > 7 > 2012-2017

Background The American Joint Committee on Cancer’s 8th edition introduced ypStage, a separate staging system for patients with gastric cancer having undergone preoperative therapy. Overall, ypN0 patients have better survival outcomes than ypN+ patients. However, whether patients with cN+/ypN0 disease (“downstaged N0”) and those with cN0/ypN0 disease (“natural N0”) have similar survival is unknown...

article

Preoperative chemoradiation therapy induces primary-tumor complete response more frequently than chemotherapy alone in gastric cancer: analyses of the National Cancer Database 2006–2014 using propensity score matching

Naruhiko Ikoma, Prajnan Das, Wayne Hofstetter, Jaffer A. Ajani, more

Gastric Cancer > 2018 > 21 > 6 > 1004-1013

Background The benefit of preoperative chemoradiation (CXRT) over preoperative chemotherapy alone (“chemotherapy” hereafter) is unknown. By analyzing the National Cancer Database (NCDB), we investigated whether preoperative CXRT improves the incidence of primary tumor pathologic complete response (ypT0) and overall survival (OS) compared with preoperative chemotherapy in patients with gastric cancer...

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INFONA - science communication portal

Search results for: Jaffer A. Ajani

Concurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival

Relationship between initial management strategy and survival in patients with gastric outlet obstruction due to gastric cancer

Impact of tumor regression grade on recurrence after preoperative chemoradiation and gastrectomy for gastric cancer

The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective

Gastric cancer in the remnant stomach after pancreaticoduodenectomy: A case series

LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma

Characteristics and Survival of Gastric Cancer Patients with Pathologic Complete Response to Preoperative Therapy

The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumors

Biomarker analysis of the GATSBY study of trastuzumab emtansine versus a taxane in previously treated HER2-positive advanced gastric/gastroesophageal junction cancer

Laparoscopic Hyperthermic Intraperitoneal Chemotherapy is Safe for Patients with Peritoneal Metastases from Gastric Cancer and May Lead to Gastrectomy

Targeting Angiogenesis in Colorectal Carcinoma

Cancer stem cells in esophageal cancer and response to therapy

The ypT category does not impact overall survival in node negative gastric cancer

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

Comprehensive Characterization of Cancer Driver Genes and Mutations

Surgeon Assessment of Gastric Cancer Lymph Node Specimens with a Video of Technique

Severe lymphopenia during neoadjuvant chemoradiation for esophageal cancer: A propensity matched analysis of the relative risk of proton versus photon-based radiation therapy

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Nodal Downstaging in Gastric Cancer Patients: Promising Survival if ypN0 is Achieved

Preoperative chemoradiation therapy induces primary-tumor complete response more frequently than chemotherapy alone in gastric cancer: analyses of the National Cancer Database 2006–2014 using propensity score matching

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