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Formins are regulators of actin filament dynamics. We demonstrate here that two formins, FHOD‐1 and EXC‐6, are important in the nematode Caenorhabditis elegans for ovulation, during which actomyosin contractions push a maturing oocyte from the gonad arm into a distensible bag‐like organ, the spermatheca. EXC‐6, a homolog of the disease‐associated mammalian formin INF2, is highly expressed in the spermatheca,...
Formins are regulators of actin filament dynamics. We demonstrate here that two formins, FHOD‐1 and EXC‐6, are important in the nematode Caenorhabditis elegans for ovulation, during which actomyosin contractions push a maturing oocyte from the gonad arm into a distensible bag‐like organ, the spermatheca. EXC‐6, a homolog of the disease‐associated mammalian formin INF2, is highly expressed in the spermatheca,...
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