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Oxidation of protein methionines to methionine‐sulfoxides (MetOx) is associated with several age‐related diseases. In healthy cells, MetOx is reduced to methionine by two families of conserved methionine sulfoxide reductase enzymes, MSRA and MSRB that specifically target the S‐ or R‐diastereoisomers of methionine‐sulfoxides, respectively. To directly interrogate MSRA and MSRB functions in cellular...