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ObjectiveWe examined the interrelationships of pituitary thyrotropin (TSH) with circulating thyroid hormones to determine whether they were expressed either invariably or conditionally and distinctively related to influences such as levothyroxine (L‐T4) treatment.
Design and methodsThis prospective study employing 1912 consecutive patients analyses the interacting equilibria of TSH and free triiodothyronine...
To examine the merits of measuring free analytes by ultrafiltration using either diluted or undiluted serum.Confidence in the accuracy of measurements is affected both by problems identified in current systems using semipermeable membranes, the sensitivity of the system to artefacts and comparisons with other imperfect assays.All “gold standard” methods must robustly obey sound physicochemical principles...
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