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Context Premature pubarche (PP) is reported in children with Prader–Willi Syndrome (PWS). Pubarche is preceded by adrenarche – an increase in serum levels of adrenal androgens, most specifically dehydroepiandrosterone sulphate (DHEAS).
Objectives To assess DHEAS levels, the age at and progression of pubarche and the prevalence of PP in children with PWS.
Design/Patients In the Dutch PWS Cohort...