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Background. The activating mutations KIT(V560G) and KIT(D816V) are associated with mastocytosis. Thus, identifying and inhibiting the signalling pathways associated with mutated KIT gene offers a potentially important strategy for the treatment of mastocytosis.
Aim. To correlate KIT mutations with specific signalling pathways in human mast‐cell lines using pathway inhibitors.
Methods. Human mast‐cell...
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