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Abnormal degradation of matrix components due to dysregulated expression of matrix metalloproteinase (MMP)‐9 in macrophages has been linked to progression of acute cerebral ischemia and atherosclerosis. We report that lithium chloride (LiCl) or CHIR99021, inhibitors of Wnt signaling pathway, enhance phosphorylation of glycogen synthase kinase‐3beta and suppress lipopolysaccharide‐mediated upregulation...