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In recent years, numerous studies have reported on the anti‐tumor properties of artemisinin and its derivatives. However, the relationship between their artemisinin chirality and activity remains unknown. In this study, we synthesized a series of artemisinin dimer derivatives with three different chiral structures and tested their antiproliferative activity in MCF‐7 and HepG2 cells using the CCK‐8...
Front Cover. Artemisinin is extracted from Artemisia annua L. Its derivative, dihydroartemisinin (DHA), is divided into α and β configuration based on the orientation of hydroxy groups on the 10th carbon. Starting from DHA as the raw material, modifications of the C‐10 position were made, and artemisinin dimer derivatives with varying chiral structures were synthesized by linking different motifs...
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