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Noscapine an FDA‐approved antitussive agent. With low cytotoxicity with higher concentrations, noscapine and its derivatives have been shown to have exceptional anticancer properties against a variety of cancer cell lines. In order to increase its potency, in this study, we synthesized a series of new amido‐thiadiazol coupled noscapinoids and tested their cytotoxicity in vitro. All of the newly synthesised...
The scaffold structure of noscapine (an antitussive plant alkaloid) was modified by inducting N‐aryl methyl pharmacophore at C‐9 position of the isoquinoline ring to rationally design and screened three novel 9‐(N‐arylmethylamino) noscapinoids, 15–17 with robust binding affinity with tubulin. The selected 9‐(N‐arylmethylamino) noscapinoids revealed improved predicted binding energy of −6.694 kcal/mol...
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