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The T box antiterminator RNA element is an important component of the T box riboswitch that controls the transcription of vital genes in many Gram‐positive bacteria. A series of 1,4‐disubstituted 1,2,3‐triazoles was screened in a fluorescence‐monitored thermal denaturation assay to identify ligands that altered the stability of antiterminator model RNA. Several ligands were identified that significantly...
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