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Aim
To investigate the association between proton pump inhibitors (PPIs) and both all‐cause and cause‐specific mortality.
Methods
We conducted a cohort study using the UK Clinical Practice Research Datalink GOLD database. We compared 733 885 new users of PPIs to 124 410 new users of H2 receptor antagonists (H2Ras). In a secondary analysis we compared 689 602 PPI new users to 1 361 245 nonusers...