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NBCe1‐A membrane‐embedded macromolecules that cotransport sodium and bicarbonate ions across the bilayer serve to maintain acid–base homeostasis throughout the body. Defects result in a number of renal and eye disorders, including type‐II renal tubular acidosis and cataracts. Here, crystals of a human truncated mutant of the cytoplasmic N‐terminal domain of NBCe1 (Δ1–62NtNBCe1‐A) are reported that...