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AimsWe investigated the effects and underlying molecular mechanism of transient receptor potential vanilloid 1 (TRPV1), a calcium (Ca2+)‐permeable non‐selective cation channel, on phosphorylation of endothelial nitric oxide synthase (eNOS) at threonine 497 (Thr497) in bovine aortic endothelial cells (BAECs) and in mice.
MethodsWestern blotting and immunoprecipitation were used for the evaluation...
AimWe investigated whether transient receptor potential vanilloid type 1 (TRPV1) was involved in the therapeutic effect of evodiamine, a main bioactive component in the fruit of Evodiae rutaecarpa, on the development of atherosclerosis in apolipoprotein E‐deficient (ApoE−/−) mice and ApoE−/−TRPV1−/− mice.
MethodsHistopathology was examined by haematoxylin and eosin staining, levels of cytokines and...
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