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Aim: The role of the volume regulated anion channel (VRAC) in a model CNS neuronal cell line, CAD, was investigated.
Methods: Changes in cell volume following hypotonic challenges were measured using a video‐imaging technique. The effect of the Cl− channel antagonists tamoxifen (10 μm) and 4,4′‐diisothiocyanatostilbene‐2,2′‐disulphonic acid (DIDS; 100 μm) on regulatory volume decrease (RVD) were...