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The eye lens is not only a radiosensitive tissue, but also one where the response to ionising radiation (IR) is cell location specific. Moreover this behaviour affects the emergent properties of the cells in the lens epithelium causing deregulation of the normally geometrically constrained epithelial cells as that transition from the germinative zone to the meridional rows at the very periphery of...
Summary
Recent work has identified a nonlinear biological response to low dose radiation in support of the low dose hormesis model in the murine lens epithelium, with mice being irradiated with doses between 0.1 and 1 Gy, with the dose response peaking at 0.5 Gy (Markiewicz et al., 2015). An important question is whether other epithelia show similar low dose hormetic responses and whether there are...